The Raw Foods Evolution

Tuesday, October 03, 2006

Diabetes and Mercury Poisoning

This article discusses Diabetes relationship to mercury poisoning.

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Diabetes and Mercury Poisoning
International Medical Veritas Association

On August 1st of 2006 the American Chemical Society published research that
showed conclusively that Methylmercury Induces Pancreatic Cell Apoptosis and
Dysfunction. [1] Mercury is a well-known toxic agent that produces various
types of cell and tissue damage yet governmental health agencies diminish this
fact exposing billions of people to levels of mercury harmful to pancreatic
health. In the case of diabetes mercury is especially telling for it affects
the beta cells, the insulin itself, and the insulin receptor sites setting off
a myriad of complex disturbances in glucose metabolism.

Metals such as iron, arsenic, lead, aluminum, other chemicals and pharmaceutical drugs are also playing a role in the disruption of glucose metabolism as we will examine in another chapter. But mercury leads the pack in the potency of its toxicity and in the pervasiveness of it presence in the environment, medicine and dentistry. Doctors who administer mercury laden vaccines and dentists who plant highly toxic mercury in people’s mouths in the form of dental amalgam cannot seem to see the forest from the trees and curb their use of it.

Thiol poisons, especially mercury and its compounds, reacting with SH groups of proteins lead to the lowered activity of various enzymes containing sulfhydryl groups. This produces a series of disruptions in the functional activity of many organs and tissues of the organism. Professor I.M. Trakhtenberg[ 2] Russia

Enzymes are proteins, and like all proteins they consist of chains of amino
acids. These chains have to be faulted in a specific way to give the enzyme
its activity. In many enzymes, the structure of the enzyme is ensured by
cross-bonding of the amino-acid chains. These cross-bonds consist of double
sulfur bonds. Sulfur-bridges are covalent S-S bonds between two cysteine amino
acids, which tend to be quite strong. These sulfur bonds are damaged when
poisonous substances that are not naturally present have been added to the local
environment. Mercury binds to the -SH (sulfhydryl) groups, resulting in
inactivation of sulfur and blocking of enzyme functions while producing sulfur
metabolites with high toxicity that the body has difficulty dealing with. Sulfur
is essential in enzymes, hormones, nerve tissue, and red blood cells. These
sulfur bonds are crucial to human biology.

Insulin is synthesized in significant quantities only in Beta cells in the
pancreas and is secreted primarily in response to elevated blood
concentrations of glucose. Each insulin molecule consists of precisely 2 peptide chains
(A and B) bound together by sulfa bonds at the A7-B7 Cysteine site and at the
A20-B19 Cysteine site and there is an additional Cysteine sulfa bond at the
A6-A11. All insulin molecules consist of this two chain structure, with an A
chain of 21 amino acids and a B chain of 30 amino acids, for a total of 51
amino acid molecules bound by 3 sulfa bonds. Mercury, in its various forms,
has a great attraction to the sulfhydryls or thiols – these sulfa bonds. A
thiol is any organic compound containing a univalent radical called a sulfhydryl
and identified by the symbol -SH (sulfur-hydrogen) .

Various molecules or atoms will affect the rate of an enzyme catalyzed
reaction by binding to the enzyme. Some bind at the same site as the substrate
(the active site) and prevent the substrate from binding. Others bind at sites
on the enzyme remote from the active site and affect activity by modifying the
shape of the enzyme. Many of these molecules reduce the activity of the
enzyme and are referred to as inhibitors. Mercury is the most potent enzyme
inhibitor that exists; it is in a class of its own and well deserves its title as
the most toxic non-radioactive element. It is because mercury and lead attach
themselves at these highly vulnerable junctures of proteins that they find
their great capacity to provoke biochemical shifts and then morphological
changes in the body. Transsulfuration pathways in the body are fundamental for
life. When mercury blocks thiol groups cellular proteins lose their reactive
properties, lose their ability to carry out their routine function.

Because glycemic regulation is one of the body’s most central homeostatic
mechanisms, mercury’s attack is most problematic,
even at low concentrations, and
indicates that it is playing a great role in the dramatic rise in
diabetes.[3]

Insulin has three sulfur-containing cross-linkages and the insulin receptor
has a tyrosine kinase-containing sulfur bond, which are the preferred targets
for binding by both mercury and lead. Should mercury attach to one of these
three sulfur bonds it will interfere with the normal biological function of
the insulin molecule. The average adult inhales thousands of trillions of
mercury atoms a day from a mouth full of amalgam, fish provide trillions more,
the air more, and in children, vaccines provide one day surges of vast
trillions of mercury molecules in the form of ethyl-mercury, which is vastly more
toxic than metallic mercury. Insulin molecules are directly assaulted as are
insulin receptor sites.

Insulin - one of the body's most important hormones –
interacts with a cell and is governed
by the shape of the insulin receptor.

Equally vulnerable to mercury’s ruin are the receptor tyrosine kinases
(RTKs) which are glycoproteins that transduce insulin’s extracellular signal to
the cytoplasm of the cell. It functions as an enzyme that transfers phosphate
groups from ATP to tyrosine residues on intracellular target proteins. The RTK
insulin receptor is comprised of two extracellular alpha chains
disulfide-linked to two membrane-spanning beta chains. Like the receptors for other
protein hormones, the receptor for insulin is embedded in the plasma membrane.
The effects of insulin are mediated by the insulin receptor (specific RTK for
insulin), and when insulin binds with its receptor, the receptor activates and
recruits a whole chain of downstream signaling processes.

The insulin receptor is no ordinary protein. It is about 200 times bigger
than insulin itself, it is actually two identical molecules intertwined.

The three dimensional crystal structure of insulin-like growth factor 1
(IGF1) receptor provides a clue to the complete vulnerability of humans when it
comes to mercury’s destructive power that can lead to diabetes. The molecular
structure of both IGF1 and the RTK insulin receptor sites are rich in
cysteines and as such we find an array of disulfide-linked modules that mercury
penetrates. Published studies from Northeastern University with thimerosal show
that it inhibits the ability of insulin-like growth factor-1 (IGF-1) to
activate the enzyme methionine synthase. Decreased activity of IGF-1 signaling is
associated with type 1 diabetes, particularly a failure of signaling in
insulin-secreting beta islet cells.

It is these protein's folds, coils, twists, and contours
that govern their interaction with insulin.
Much like the key to your front door fits perfectly with its lock and no
others, an insulin receptor is like the lock and insulin is like the key.

A single preliminary experiment at the Joslin Diabetes Clinic showed that
thimerosal (ethyl-mercury) inhibits an early step in the signaling pathway.
Studies at Northeastern also provided evidence that Cu2+ stimulates the IGF-1
signaling pathway, and it appears that thimerosal is also interfering with this
normal activity. Some doctors have speculated about vaccines being
responsible for the increases we are seeing in children’s diabetes but now it is
becoming clearer that children’s systems are under a broad mercury attack with
each source, type of mercury, and mode and timing of contamination setting
stages for different pathologies.

The general model of insulin activity indicates that one insulin molecule
engages the cystein-rich domain of the receptor, touching down on both sides of
protein chain that are separated by the disulfide bond. If the geometry of
the receptor has been changed by mercury the message that insulin has arrived
to give glucose to the cell is not received. Mercury is an inhibitor capable
of interfering with PTK catalytic activity exactly because it is
collapsing/damaging these sulfur-containing cross-linkages which changes the geometry of
both insulin receptor and insulin itself.

It is reasonable to assume a direct correlation between rising environmental
mercury levels, mercury exposure through dental amalgam, heavy fish
consumption and exposure to mercury in vaccines with the rapidly expanding diabetic
pandemic, not to mention the host of drugs and even chemicals put into foods
that are part of the diabetic equation. The medical establishment is dragging
its collective ass when it comes to understanding the causes of diabetes and
thus is remaining impotent in the face of a steadily worsening human
catastrophe. It is perfectly clear though to health officials that the diabetic
epidemic is expanding rapidly but because they scratch their heads about chemical
causes they remain incapable of arresting the pandemic.

Medical and health officials seem to live in an unconscious fog when it
comes to mercury even though Methylmercury (MeHg) induces oxidative stress and
cell cytotoxicity through mitochondrial apoptosis[4] pathways.

New information shows that in the United States alone 50 million are pre
diabetic,[5] up from estimates of 41 million only two short years ago and this
could correlate with the rapidly escalating production of mercury pollution
coming from China , which is contributing greatly to increased world wide
mercury exposure. Some say we are all receiving, just through our air, water and
food about a microgram of mercury a day. Sounds like little until you calculate
that a microgram contains 3,000 trillion atoms with each of them holding the
potential to deactivate insulin and the receptor sites crucial to their
function.

Mercury can induce apoptosis in human T lymphocytes.
The target organelle was the mitochondrion and that induction of oxidative
stress led to activation of death-signaling pathways.[6]

The official position of medical, dental and governmental agencies is that
there have been virtually no cases of mercury poisoning in the United States
so they cannot understand what all the fuss is about from environmentalists
and health activists who are confronting industry and both dentists and doctors’
obscene use of mercury. We hear statements like, "There is a misguided fear
out there," said Dr. Ed Hewlett of the American Dental Association. "In
order to have even the earliest signs of a problematic effect with mercury
fillings, a person would have to have 500 silver fillings in their mouth, all at
the same time." Doctors say the same about mercury in vaccines finding no
problem injecting infants with thimerosal containing vaccines. It is apparent that
governments in the United States and China are not interested in investing
money in reducing the amount of mercury coming out of coal burning smoke
stacks or other point sources of mercury pollution. Instead we have vast
propaganda campaigns diminish the public danger while encouraging fish consumption,
flu and other vaccines containing mercury, and dental amalgam as safe.

MeHg triggers ROS production, suppresses insulin secretion,
and induces apoptosis in -cell-derived HIT-T15 cells
and isolated mouse pancreatic islets.
College of Medicine , Taiwan University

Mercury has always been known as a toxic metal that induces oxidative
stress. Since it has also been known that pancreatic cells are vulnerable to
oxidative stress it should come as no surprise that researches have found that the
rising tide of mercury in the environment is pushing a worldwide epidemic in
both type 1 and 2 diabetes. Also of no surprise is that this research showed
that antioxidant N-acetylcysteine effectively is able to reverse MeHg-induced
cellular responses.

The Researchers in Taiwan say they have established for the first time that
the mercury compound present as a contaminant in some seafood can damage the
insulin-producing cells in the pancreas. In their experiments, Shing-Hwa Liu
and colleagues exposed cell cultures of insulin-producing beta cells to
methylmercury. They used concentrations of methylmercury at about the same levels
as people would consume in fish under the U. S. Food and Drug
Administration' s recommended limits.

It has been shown that an increased incidence of diabetes existed in
patients with documented Minamata disease (MeHg poisoning) in Japan.[7] Takeuchi et
al. reported that the disturbance of pancreatic islet cells was found in
autopsy cases of Minamata disease.[8] In experiments using rats, Shigenaga has
found that pancreatic islets were injured by MeHg and that a high level of
blood glucose was induced by repeated administration of MeHg.[9]

It has been suggested in the past that pancreatic beta cells might be rather
sensitive to reactive oxygen species (ROS)[10] attack when they are exposed
to oxidative stress,[11] because of the relatively low _expression of
antioxidant enzymes such as catalase and glutathione peroxidase.[ 12] Diabetes is
typically accompanied by an increased production of free radicals and/or impaired
antioxidant defense capabilities, indicating a central contribution of
reactive oxygen species. It is a fact that ROS is one of the major factors that
induce oxidative modification of DNA and gene mutation.[13]

MeHg significantly increased ROS levels.

ROS is involved in the onset, progression, and pathological consequences of
diabetes.[14] The study published by the American Chemical Society showed
that MeHg is capable of suppressing insulin secretion of pancreas cells through
a ROS-triggered pathway. MeHg-induced oxidative stress causes pancreatic beta
cell apoptosis and dysfunction. What this means is that right under doctors
and medical officials noses millions are having their lives ruined.

When it comes to mercury vaccines EPA safety levels are exceeded as a vast
number of organic mercury molecules enter the system in one moment but again
health officials step in with what can only be seen as an obscene idea that
suggests that one-day exposures can be averaged out through many months. It’s
like saying one can take six months of heart medication all in one day.
Someday it will dawn on both dentists and doctors who use mercury that they are
actually poisoning children and people.

Because mercury is increasingly becoming elevated in all forms of life, we
can assume that more people will have some defects in pancreatic function.
Pancreatic support is increasingly necessary for optimal health.
Dr. Garry Gordon

Most doctors are lost in their force fed concepts when it comes to diabetes
and this blinds them to a tragedy of staggering proportions. The same can be
said of the medical establishment and autism but parents have independently
found out that detoxification and chelation treatments that reduce mercury and
other toxic chemical body burdens helps their children. It is a totally new
idea that reducing mercury exposure and eliminating (chelating) mercury from
the body can reduce, stabilize or even be part of a cure for the diabetic
condition.

Mercury is now part of the human weather with clouds billowing around the
upper atmosphere. The government can doubt all it wants about planetary warming
and the human factor involved in it. They try the same game about mercury
trying to deflect the problem by stating there is and always have been large
scale natural emissions of mercury. But there is no doubting the rising tonnage
(approximately 20 tons a day) put into the air everyday by human activity.
That’s a lot of mercury and it’s showing up in the quickly escalating
diabetes statistics.

Mark Sircus Ac., OMD
Director International Medical Veritas Association
http://www.imva. info
http://www.magnesiu mforlife. com

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Comment from Michael Snyder:

Natural Cellular Defense liquid zeolite is scientifically proven to remove the heavy metals, many of the environmental and industrial chemicals, as well as stop virus's from replicating. It has a chelation-like effect in removing heavy metals (particularly lead, mercury, cadmium, and arsenic), pesticides, herbicides, PCBs, and other toxins from the body. In addition to what it was patented for, that being as a treatment and prevention for epithelial cell cancers.

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